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Simone Dusek is a Doctor with the CDC- (Centers for Disease Control and Prevention) who was seen briefing Hawaii Five-0 Task Force member, Officer Kono Kalakaua on the effects of weaponized smallpox during the Hawaii Five-0 Season 2 episode, Episode:Pa Make Loa (Hawaii Five-0).

She later contacted Kono to inform her that the virals that Kono's colleagues, Danny Williams and Kono's cousin, Chin Ho Kelly as well as NCIS Special Agents G. Callen and Sam Hanna had recovered from Dracul Comescu did not contain smallpox, forcing the team to head to Honolulu International Airport and then eventually Los Angeles after learning that a possible suspect had arrived in LA with the smallpox virals.

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